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Consensus Guidelines for Drug Resistance Testing
Because the treatment of HIV is constantly evolving, up-to-date consensus recommendations and guidelines outlining the latest therapy
trends and practices are highly valuable. Most of the recently published guidelines now include recommendations for the use of drug
resistance testing as a tool in therapy planning.
Antiretroviral Drug Resistance Testing in Adults Infected with Human Immunodeficiency Virus Type 1: 2003 Recommendations of an
International AIDS Society — USA Panel (2003)¹
Summary: drug resistance testing is recommended in cases of acute or recent HIV infection, for certain patients who have been
infected as long as 2 years or more prior to initiating therapy, in cases of antiretroviral failure, and during pregnancy.
Click here to view the complete recommendations.
Guidelines for the Use of Antiretroviral Agents in HIV-1 Infected Adults and Adolescents; Panel on Clinical Practices for
Treatment of HIV Infection convened by The Department of Health and Human Services (DHHS) (7/2003)²
Summary: Drug resistance testing is recommended for virologic failure during combination antiretroviral therapy, suboptimal
suppression of viral load after antiretroviral therapy initiation, and acute human immunodeficiency virus (HIV) infection, if
decision is made to initiate therapy. Drug resistance testing should be considered for chronic HIV infection before therapy initiation.
The recommendations for resistance testing during pregnancy are the same as for nonpregnant persons.
Click here to view the guidelines.
References:
1. Hirsch MS, Brun-Vezinet F, Bonaventura C, et al. Antiretroviral drug resistance testing in adults infected with human immunodeficiency
virus type 1: 2003 recommendations of an international AIDS society-USA panel. CID. 2003;37:113-128.
2. Department of Health and Human Services (DHHS): Panel on Clinical Practices for Treatment of HIV Infection. Guidelines for
the use of antiretroviral agents in HIV-1 infected adults and adolescents. July 14, 2003. Pages 5-6, 42.
Available at http:// AIDSinfo.nih.gov.
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